Maternal circulating SPINT1 is reduced in small-for-gestational age pregnancies at 26 weeks: Growing up in Singapore towards health outcomes (GUSTO) cohort study

TJ Kaitu'u-Lino; S Tong; SP Walker; TM MacDonald; P Cannon; TV Nguyen; SA Sadananthan; MT Tint; YY Ong; LS Ling; PD Gluckman; YS Chong; KM Godfrey; SY Chan; KH Tan; YS Lee; N Michael; JG Eriksson; ME Wlodek

Journal article

Maternal circulating SPINT1 is reduced in small-for-gestational age pregnancies at 26 weeks: Growing up in Singapore towards health outcomes (GUSTO) cohort study

TJ Kaitu'u-Lino, S Tong, SP Walker, TM MacDonald, P Cannon, TV Nguyen, SA Sadananthan, MT Tint, YY Ong, LS Ling, PD Gluckman, YS Chong, KM Godfrey, SY Chan, KH Tan, YS Lee, N Michael, JG Eriksson, ME Wlodek

Placenta | Published : 2021

DOI: 10.1016/j.placenta.2021.05.007

Abstract

Fetal growth restriction arising from placental insufficiency is a leading cause of stillbirth. We recently identified low maternal circulating SPINT1 concentrations as a novel biomarker of poor fetal growth. Here we measured SPINT1 in a prospective cohort in Singapore. Circulating SPINT1 concentrations were significantly lower among 141 pregnant women destined to deliver small-for-gestational age infants (birthweight <10th centile), compared to 772 controls (p < 0.01) at as early as 26 weeks’ gestation. There were no correlations between infant body composition and circulating SPINT1 concentrations at 26 weeks. This provides validation that low maternal SPINT1 concentration is associated wi..

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University of Melbourne Researchers

Tu'uhevaha Kaitu'u-Lino Author

Stephen Tong Author

Susan Walker Author

Teresa MacDonald Author

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Grants

Awarded by Medical Research Council

Funding Acknowledgements

KMG is supported by the UK Medical Research Council (MC_UU_12011/4), the National Institute for Health Research (NIHR Senior Investigator (NF-SI-0515-10042), NIHR Southampton 1000DaysPlus Global Nutrition Research Group (17/63/154) and NIHR Southampton Biomedical Research Centre (IS-BRC-1215-20004)), the European Union (Erasmus+ Programme ImpENSA 598488-EPP-1-20181-DE-EPPKA2-CBHE-JP) and the British Heart Foundation (RG/15/17/3174).